We design, produce, and deliver custom DNA Donors for use as homology-directed repair (HDR) templates in genome editing. Our Gatalyst™ (stands for Genome Catalyst) technology benefits multiple aspects of gene editing and cell engineering with potential to impact diverse fields and markets in the life sciences.
The Stellate DNA Gatalyst™ platform is a proprietary integrated suite of technologies to design, synthesis, and manufacture single-strand DNA donors for high efficiency, low cell toxicity, large-size enabled (up to 20 kb) HDR (homology directed repair) based gene knockin payload using CRISPR-Cas9 system.
The Stellate Gatalyst™ donor is in a circular form which minimizes the non-homologous interaction between the donor and the genome loci other than the editing target region. The circular formation also protects the donor from degradation more efficiently which ensures a longer half life comparing with the linearized single-strand donor.
The Stellate DNA Gatalyst™ platform utilizes clonal rather than chemical synthesis to manufacture the customizable gene knock-in payload which guarantees not only microgram to milligram scale production with well-controlled cost but also ensures the minimal mutation rate and sequence uniformity.
The Stellate DNA Gatalyst™ platform is flexible to generate your preferred ssDNA donor the same way as you design plasmid DNA. This new generation of gene editing donor production system will advance the gene editing field into an efficient, highly cost-effective, high throughput era that can expedite cell engineering, animal model generation and cancer therapeutic research.