We design, produce, and deliver custom DNA donors for use as homology-directed repair (HDR) templates in genome editing. The Gatalyst™ (Genome Catalyst) technology benefits multiple aspects of gene editing and cell engineering with potential to impact diverse markets in the life sciences.
The Stellate DNA Gatalyst™ platform is an integrated suite of technologies to design and manufacture single-stranded DNA donors for high efficiency, low cell toxicity, large-size enabled (up to 20 kb) homology directed repair (HDR) based knock-ins of payloads using the CRISPR-Cas9 system.
The Stellate Gatalyst™ donor is in a circular form which minimizes the non-homologous interaction between the donor and the genome loci other than the editing target region. The circular formation also protects the donor from degradation more efficiently which ensures a longer half-life compared with the linearized single-strand donor.
The Stellate DNA Gatalyst™ platform utilizes clonal rather than chemical synthesis to manufacture the customizable gene knock-in payload which guarantees not only microgram to milligram scale production with well-controlled cost but also ensures a minimal mutation rate and sequence uniformity.
The Stellate DNA Gatalyst™ platform is flexible and allows you to design your preferred ssDNA donor. Gatalyst™ gene editing donors will advance the gene editing field into a high-throughput era to expedite cell engineering, animal model generation and therapeutic research.