We design, produce, and deliver custom DNA Donors for use as homology-directed repair templates in Genome Modification. Our technology benefits multiple aspects of gene editing and cell engineering with potential to impact diverse fields and markets in the Life Sciences.
Personalized cell therapies are engineered by viral gene delivery methods because CRISPR cannot make large knock-ins. Stellate DNA Donors direct large edits, up to 20 kb, while retaining CRISPR's hallmark feature -- precise targeting.
Stellate DNA Donors increase editing efficiency and decrease cytotoxicity across cell types. This facilitates achieving a critical mass of engineered cells (CAR-T), and making edits in super-sensitive cell types (zygotic and stem cells).